production and quality control of 166ho-chitosan for therapeutic applications
نویسندگان
چکیده
introduction: in this research, [166ho]holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. finally a ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed.methods: 166ho-chitosan complex was prepared using chitosan concentrations and 166hocl3 followed by intra-articular injection and biodistribution studies in wild-type rats including and excluding injected knee.results: the [166ho]holmium chitosan complex was prepared with high radiochemical yield (>95 %) in the optimized condition (35mg/3ml of chitosan in %1 acoh, ph. 3, >98%, itlc) was injected to wild-type rats followed by the biodistribution studies of the compound among the tissues excluding the injected knee data. intra-articular injection of [166ho]holmium chitosan complex to male wild-type rats and investigation of leakage of activity in the body showed that most of injected dose has remained in injection site 144 h after injection. conclusion: successful development and formulation of 166ho-chitosan kit is described. this kit has the potential for use in clinical setting namely for radiosynovectomy and cancer radiochemotherapy.
منابع مشابه
Production and quality control of 166Ho-Chitosan for therapeutic applications
Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: 166</s...
متن کاملProduction and Quality Control of Ho-Chitosan for Therapeutic Applications
Introduction: In this research, [Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: Ho-chitosan complex was pr...
متن کاملProduction, Quality Control and Pharmacokinetic Studies of 166Ho-EDTMP for Therapeutic Applications
(166)Ho-EDTMP is a major therapeutic agent which is widely used in bone palliation therapy. In this study, a (166)Ho-EDTMP complex was prepared successfully using an in-house synthesized EDTMP ligand and (166)HoCl(3). Ho-166 chloride was obtained by thermal neutron irradiation (1 Ã 10(13) ncm(â2)s(â1)) of natural Ho(NO(3))(3) samples (specific activity = 3â5 GBq/mg), dissolved in acidic media. ...
متن کاملProduction, Quality Control and Biological Evaluation of 166Ho-PDTMP as a Possible Bone Palliation Agent
Objective(s):In this study, 166Ho-1,2-propylene di-amino tetra(methy1enephosphonicAcid) (166Ho-PDTMP) complex was prepared as a bone palliation agent. Materials and Methods:The complex was successfully prepared using an in-house synthesized EDTMP ligand and 166HoCl3. Ho-166 chloride was obtained by thermal neutron irradiation (1 × 1013 n.cm-2.s-1) of natural Ho(NO3)3 samples followed by radio...
متن کاملProduction, quality control and imaging of 64Cu-ATSM in healthy rabbits for clinical applications
Introduction: [64Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]ATSM) is a well-established hypoxia imaging tracer with reproducible production and significant specifity. In this work the high yield production and quality control as well as imaging studies in healthy rabbits is reported. Methods: Copper-64 produced ...
متن کاملPreparation and quality control of 177Lu-chitosan for radiosynovectomy
Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Se...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of nuclear medicineناشر: tehran university of medical sciences
ISSN 1681-2824
دوره 18
شماره 2 2010
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023